Interleukin 6 and complement serum level study in Parkinson's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068907" target="_blank" >RIV/00159816:_____/18:00068907 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/18:00103549

Result on the web

<a href="http://dx.doi.org/10.1007/s00702-018-1857-5" target="_blank" >http://dx.doi.org/10.1007/s00702-018-1857-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-018-1857-5" target="_blank" >10.1007/s00702-018-1857-5</a>

Result language

angličtina

Original language name

Interleukin 6 and complement serum level study in Parkinson's disease

Original language description

The objective of this study is to assess whether elevation of serum inflammatory markers levels may indicate the progression of clinical impairment in Parkinson&apos;s disease (PD) patients. In 47 PD patients, the serum levels of the C3 and C4 part of the complement and Interleukin-6 (IL-6) were measured. The results at baseline and after 2 years were correlated with scales measuring memory, depression, motor symptoms, and quality of life. Patients with higher levels of C3 and C4 at baseline had decreased quality of life, verbal ability, and memory. Patients with higher IL-6 at baseline showed worse depression scores at 2 years. Patients with persistently higher levels of C3 and C4 at 2 years had worse quality of life and memory ability. Uncorrected p values are reported due to the exploratory nature of the study. The results indicate an impact of inflammation on non-motor signs and quality of life in PD. The increase of levels of serum inflammatory biomarkers may indicate the progression of non-motor impairment in PD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

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Volume of the periodical

125

Issue of the periodical within the volume

5

Country of publishing house

AT - AUSTRIA

Number of pages

7

Pages from-to

875-881

UT code for WoS article

000430583400010

EID of the result in the Scopus database

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