White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068984" target="_blank" >RIV/00159816:_____/18:00068984 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/18:00105511

Result on the web

<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187939" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187939</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0187939" target="_blank" >10.1371/journal.pone.0187939</a>

Result language

angličtina

Original language name

White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy

Original language description

Introduction While progressive MRI brain changes characterize advanced Parkinson&apos;s disease (PD), little has been discovered about structural alterations in the earliest phase of the disease, i.e. in patients with motor symptoms and with normal cognition. Our study aimed to detect grey matter (GM) and white matter (WM) changes in PD patients without cognitive impairment. Methods Twenty PD patients and twenty-one healthy controls (HC) were tested for attention, executive function, working memory, and visuospatial and language domains. High-resolution T1-weighted and 60 directional diffusion-weighted 3T MRI images were acquired. The cortical, deep GM and WM volumes and density, as well as the diffusion properties of WM, were calculated. Analyses were repeated on data flipped to the side of the disease origin. Results PD patients did not show any significant differences from HC in cognitive functioning or in brain volumes. Decreased GM intensity was found in the left superior parietal lobe in the right (p&lt;0.02) and left (p&lt;0.01) flipped data. The analysis of original, un-flipped data demonstrated elevated axial diffusivity (p&lt;0.01) in the superior and anterior corona radiata, internal capsule, and external capsule in the left hemisphere of PD relative to HC, while higher mean and radial diffusivity were discovered in the right (p&lt;0.02 and p&lt;0.03, respectively) and left (p&lt;0.02 and p&lt;0.02, respectively) in the fronto-temporal WMutilizing flipped data. Conclusions PD patients without cognitive impairment and GM atrophy demonstrated widespread alterations of WM microstructure. Thus, WM impairment in PD might be a sensitive sign preceding the neuronal loss in associated GM regions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

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UT code for WoS article

000419403800009

EID of the result in the Scopus database

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