Randomised comparison of a biodegradable polymer ultra-thin sirolimus-eluting stent versus a durable polymer everolimus-eluting stent in patients with de novo native coronary artery lesions: the meriT-V trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00069329" target="_blank" >RIV/00159816:_____/18:00069329 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4244/EIJ-D-18-00762" target="_blank" >http://dx.doi.org/10.4244/EIJ-D-18-00762</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4244/EIJ-D-18-00762" target="_blank" >10.4244/EIJ-D-18-00762</a>

Result language

angličtina

Original language name

Randomised comparison of a biodegradable polymer ultra-thin sirolimus-eluting stent versus a durable polymer everolimus-eluting stent in patients with de novo native coronary artery lesions: the meriT-V trial

Original language description

Aims: The aim of this study was to evaluate the safety and efficacy of the BioMime sirolimus-eluting coronary stem (SES) compared to the XIENCE family of everolimus-eluting coronary stents (EES) in the treatment of patients with de novo native coronary artery lesions. Methods and results: The meriT-V is a prospective, multicentre, randomised, open-label, active-controlled, non-inferiority trial. A total of 256 patients with up to two de novo native coronary artery lesions were enrolled and randomly assigned (2:1) to BioMime SES or XIENCE EES. BioMime SES was non-inferior to XIENCE EES for the primary endpoint of in-stent late lumen loss (0.15 +/- 0.27 mm vs. 0.15 +/- 0.29 mm; difference: -0.006 mm; 95% confidence interval: -0.085 to 0.072; p=0.87; p for non-inferiority &lt;0.0001) at nine-month follow-up. The major adverse cardiac events rate was numerically lower in the BioMime SES group (2.98% vs. 7.14%; p=0.13), driven by a statistically significant lower risk of any myocardial infarction (0.60% vs. 4.76%; p=0.03), when compared with the XIENCE EES group. There was no difference in target vessel myocardial infarction (p=0.62) between the groups. There was no definite or probable stent thrombosis in either group. Conclusions: In the treatment of de novo native coronary artery lesions, the biodegradable polymer ultrathin SES (BioMime) was non-inferior to a durable polymer EES (XIENCE) at nine-month follow-up. Further studies powered for clinical endpoints are needed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Eurointervention

ISSN

1774-024X

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

11

Country of publishing house

FR - FRANCE

Number of pages

8

Pages from-to

1207-1214

UT code for WoS article

000452498600012

EID of the result in the Scopus database

2-s2.0-85058636243