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Cancer stem cells in sarcomas: Getting to the sternness core

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00069353" target="_blank" >RIV/00159816:_____/18:00069353 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.bbagen.2018.07.006" target="_blank" >http://dx.doi.org/10.1016/j.bbagen.2018.07.006</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bbagen.2018.07.006" target="_blank" >10.1016/j.bbagen.2018.07.006</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cancer stem cells in sarcomas: Getting to the sternness core

  • Original language description

    Background: Sarcomas are rare tumors but represent the third most common malignancy in children. The cancer stem cell (CSC) paradigm is well established, and CSCs have been intensively studied in sarcomas in the past decade. Scope of review: This review summarizes current knowledge on CSCs in sarcomas and provides new perspectives on the role of a deregulated sternness program in sarcomagenesis. Major conclusions: Cell surface markers have so far failed to specifically target sarcoma CSCs. Sarcomas likely arise from immature cells that undergo pathological reprogramming. Transcription factor Sox2, which is frequently upregulated in sarcomas, is directly involved in this process, and its crucial role in the acquisition and maintenance of the CSC phenotype has been demonstrated in various sarcomas. General significance: Sox2 is a core functional regulator of the stem-like state and is an outstanding marker of sarcoma CSCs. Fluorescence protein-based reporters of Sox2 expression might provide useful tools for subsequent studies of sarcoma CSCs.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochimica et Biophysica Acta - General Subjects

  • ISSN

    0304-4165

  • e-ISSN

  • Volume of the periodical

    1862

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    2134-2139

  • UT code for WoS article

    000443665300003

  • EID of the result in the Scopus database