Cancer stem cells in sarcomas: Getting to the sternness core
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00069353" target="_blank" >RIV/00159816:_____/18:00069353 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbagen.2018.07.006" target="_blank" >http://dx.doi.org/10.1016/j.bbagen.2018.07.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbagen.2018.07.006" target="_blank" >10.1016/j.bbagen.2018.07.006</a>
Alternative languages
Result language
angličtina
Original language name
Cancer stem cells in sarcomas: Getting to the sternness core
Original language description
Background: Sarcomas are rare tumors but represent the third most common malignancy in children. The cancer stem cell (CSC) paradigm is well established, and CSCs have been intensively studied in sarcomas in the past decade. Scope of review: This review summarizes current knowledge on CSCs in sarcomas and provides new perspectives on the role of a deregulated sternness program in sarcomagenesis. Major conclusions: Cell surface markers have so far failed to specifically target sarcoma CSCs. Sarcomas likely arise from immature cells that undergo pathological reprogramming. Transcription factor Sox2, which is frequently upregulated in sarcomas, is directly involved in this process, and its crucial role in the acquisition and maintenance of the CSC phenotype has been demonstrated in various sarcomas. General significance: Sox2 is a core functional regulator of the stem-like state and is an outstanding marker of sarcoma CSCs. Fluorescence protein-based reporters of Sox2 expression might provide useful tools for subsequent studies of sarcoma CSCs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochimica et Biophysica Acta - General Subjects
ISSN
0304-4165
e-ISSN
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Volume of the periodical
1862
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
2134-2139
UT code for WoS article
000443665300003
EID of the result in the Scopus database
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