Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00070049" target="_blank" >RIV/00159816:_____/18:00070049 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00104703

Result on the web

<a href="http://dx.doi.org/10.1016/j.acthis.2017.11.001" target="_blank" >http://dx.doi.org/10.1016/j.acthis.2017.11.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.acthis.2017.11.001" target="_blank" >10.1016/j.acthis.2017.11.001</a>

Result language

angličtina

Original language name

Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells

Original language description

The aim of our study was to analyse the possible protective effect of quercetin application during the jejunal ischemia-reperfusion injury (IRI) in rats. Quercetin was administered intraperitoneally 30 min before 1 h ischemia of superior mesenteric artery with following 24 h lasting reperfusion period. The male specific pathogen-free (SPF) Charles River Wistar rats were used. In the group with applied quercetin, the significantly increased (p &lt; 0.001) levels of anti-inflammatory cytokine IL10 were observed both in the blood serum and jejunal tissue. The improvement of the mucosal tissue morphology and proliferating and DNA repairing cell number measured by PCNA activity were recorded by more than 30% higher in the quercetin group. Simultaneously, significant elongation of the intestinal glands (p &lt; 0.001) and increase in the number of CD68positive cells in the lamina propria mucosae (p &lt; 0.001) in comparison with control group were found. Based on our results, the preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects as well. CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Histochemica

ISSN

0065-1281

e-ISSN

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Volume of the periodical

120

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

28-32

UT code for WoS article

000456907200005

EID of the result in the Scopus database

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