Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070540" target="_blank" >RIV/00159816:_____/19:00070540 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/19:00109487 RIV/65269705:_____/19:00070540

Result on the web

<a href="https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00586-018-5838-z" target="_blank" >10.1007/s00586-018-5838-z</a>

Result language

angličtina

Original language name

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

Original language description

PurposeThe presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. MethodsIntervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n=25), clindamycin (n=17) or vancomycin (n=12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue.ResultsIntervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P&lt;0.0001) and vancomycin, which has a slight positive charge (P&lt;0.0001).Conclusion Positively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. Graphical abstract: These slides can be retrieved under Electronic Supplementary Material.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30211 - Orthopaedics

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Spine Journal

ISSN

0940-6719

e-ISSN

—

Volume of the periodical

28

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

783-791

UT code for WoS article

000463673200018

EID of the result in the Scopus database

2-s2.0-85057581239