MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070688" target="_blank" >RIV/00159816:_____/19:00070688 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/19:00108511 RIV/00209805:_____/19:00078175
Result on the web
<a href="http://cgp.iiarjournals.org/content/16/2/139" target="_blank" >http://cgp.iiarjournals.org/content/16/2/139</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/cgp.20119" target="_blank" >10.21873/cgp.20119</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy
Original language description
Background/Aim: Head and neck cancers are a heterogenous group of epithelial tumors represented mainly by squamous cell carcinomas (HNSCC), which are the sixth most common type of cancer worldwide. Surgery together with radiotherapy (RT) is among the basic treatment modalities for most HNSCC patients. Various biomarkers aiming to predict patients' response to RT are currently investigated. The reason behind this effort is, on one hand, to distinguish radioresistant patients that show weak benefit from RT and, on the other hand, reduce the ionizing radiation dose in less aggressive radiosensitive HNSCC with possibly less acute or late toxicity. Materials and Methods: A total of 94 HNSCC patients treated by definitive intensity-modulated radiotherapy were included in our retrospective study. We used a global expression analysis of microRNAs (miRNAs) in 43 tumor samples and validated a series of selected miRNAs in an independent set of 51 tumors. Results: We identified miR-15b-5p to be differentially expressed between patients with short and long time of locoregional control (LRC). Kaplan-Meier analysis confirmed that HNSCC patients with higher expression of miR-15b-5p reach a significantly longer locoregional relapsefree survival compared to patients expressing low levels. Finally, multivariable Cox regression analysis revealed that miR-15b-5p is an independent predictive biomarker of LRC in HNSCC patients (HR=0.25 ; 95% CI=0.05-0.78; p<0.016). Conclusion: miR-15b-5p represents a potentially helpful biomarker for individualized treatment decisions concerning the management of HNSCC patients.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30206 - Otorhinolaryngology
Result continuities
Project
<a href="/en/project/NV15-31627A" target="_blank" >NV15-31627A: Molecularly guided radiotherapy or radiochemotherapy based on mikroRNA profile in head and neck cancer patients- a feasibility study.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Genomics & Proteomics
ISSN
1109-6535
e-ISSN
—
Volume of the periodical
16
Issue of the periodical within the volume
2
Country of publishing house
GR - GREECE
Number of pages
8
Pages from-to
139-146
UT code for WoS article
000463451200004
EID of the result in the Scopus database
—