Controlling metastatic cancer: the role of phytochemicals in cell signaling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070969" target="_blank" >RIV/00159816:_____/19:00070969 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00110195
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00432-019-02892-5" target="_blank" >https://link.springer.com/article/10.1007%2Fs00432-019-02892-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00432-019-02892-5" target="_blank" >10.1007/s00432-019-02892-5</a>
Alternative languages
Result language
angličtina
Original language name
Controlling metastatic cancer: the role of phytochemicals in cell signaling
Original language description
PurposeCancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation.ResultsCurrent research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds.ConclusionsBased on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cancer Research and Clinical Oncology
ISSN
0171-5216
e-ISSN
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Volume of the periodical
145
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
23
Pages from-to
1087-1109
UT code for WoS article
000465605800001
EID of the result in the Scopus database
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