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Antimicrobial effect of commercial phage preparation Stafal (R) on biofilm and planktonic forms of methicillin-resistant Staphylococcus aureus

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071015" target="_blank" >RIV/00159816:_____/19:00071015 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/19:00108452

  • Result on the web

    <a href="https://link.springer.com/article/10.1007%2Fs12223-018-0622-3" target="_blank" >https://link.springer.com/article/10.1007%2Fs12223-018-0622-3</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s12223-018-0622-3" target="_blank" >10.1007/s12223-018-0622-3</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Antimicrobial effect of commercial phage preparation Stafal (R) on biofilm and planktonic forms of methicillin-resistant Staphylococcus aureus

  • Original language description

    Staphylococcus aureus may be a highly virulent human pathogen, especially when it is able to form a biofilm, and it is resistant to antibiotic. Infections caused by these bacteria significantly affect morbidity and mortality, primarily in hospitalized patients. Treatment becomes more expensive, more toxic, and prolonged. This is the reason why research on alternative therapies should be one of the main priorities of medicine and biotechnology. A promising alternative treatment approach is bacteriophage therapy. The effect of the anti-staphylococcal bacteriophage preparation Stafal (R) on biofilm reduction was assessed on nine S. aureus strains using both sonication with subsequent quantification of surviving cells on the catheter surface and evaluation of biofilm reduction in microtiter plates. It was demonstrated that the bacteriophages destroy planktonic cells very effectively. However, to destroy cells embedded in the biofilm effectively requires a concentration at least ten times higher than that provided by the commercial preparation. The catheter disc method (CDM) allowed easier comparison of the effect on planktonic cells and cells in a biofilm than the microtiter plate (MTP) method.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

    <a href="/en/project/NV16-29916A" target="_blank" >NV16-29916A: The use of bacteriophages in the treatment of nosocomial infections associated with multidrug resistance or biofilm formation</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Folia Microbiologica (Praha)

  • ISSN

    0015-5632

  • e-ISSN

  • Volume of the periodical

    64

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    6

  • Pages from-to

    121-126

  • UT code for WoS article

    000455916000015

  • EID of the result in the Scopus database