Caver Web 1.0: identification of tunnels and channels in proteins and analysis of ligand transport

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071059" target="_blank" >RIV/00159816:_____/19:00071059 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/19:00110115
Result on the web
<a href="https://academic.oup.com/nar/article/47/W1/W414/5494718" target="_blank" >https://academic.oup.com/nar/article/47/W1/W414/5494718</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gkz378" target="_blank" >10.1093/nar/gkz378</a>

Result language
angličtina
Original language name
Caver Web 1.0: identification of tunnels and channels in proteins and analysis of ligand transport
Original language description
Caver Web 1.0 is a web server for comprehensive analysis of protein tunnels and channels, and study of the ligands' transport through these transport pathways. Caver Web is the first interactive tool allowing both the analyses within a single graphical user interface. The server is built on top of the abundantly used tunnel detection tool Caver 3.02 and CaverDock 1.0 enabling the study of the ligand transport. The program is easy-to-use as the only required inputs are a protein structure for a tunnel identification and a list of ligands for the transport analysis. The automated guidance procedures assist the users to set up the calculation in a way to obtain biologically relevant results. The identified tunnels, their properties, energy profiles and trajectories for ligands' passages can be calculated and visualized. The tool is very fast (2-20 min per job) and is applicable even for virtual screening purposes. Its simple setup and comprehensive graphical user interface make the tool accessible for a broad scientific community. The server is freely available at https://loschmidt.chemi.muni.cz/caverweb.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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