Using Lung Organoids to Investigate Epithelial Barrier Complexity and IL-17 Signaling During Respiratory Infection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071092" target="_blank" >RIV/00159816:_____/19:00071092 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2019.00323/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2019.00323/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2019.00323" target="_blank" >10.3389/fimmu.2019.00323</a>

Result language

angličtina

Original language name

Using Lung Organoids to Investigate Epithelial Barrier Complexity and IL-17 Signaling During Respiratory Infection

Original language description

The respiratory system is the first point of contact with airborne microbial compounds. Consequently, lung mucosal immunity has been extensively studied to understand the mechanisms of host resistance to respiratory infections. The lungs exhibit highly active innate and adaptive mucosal immune mechanisms: they are infiltrated with a wide spectrum of immune cells in steady state and possess the capacity to recruit vast numbers of infiltrating cells upon infection or encounter with inflammatory stimuli. Despite the existence of such protective mechanisms, respiratory tract infections (RTIs) with epidemic and pandemic potential are one of the most common causes of morbidity and mortality worldwide. In recent years, studies using new lung culture systems, such as air liquid interface (ALI), spheroids, tissue explants and advances in DNA sequencing technology have helped identify that the upper and lower respiratory tracts represent distinct biomes in terms of their commensal microorganism colonization, immune barriers and host defense mechanisms (1-3). Most lower respiratory tract infections (LRTIs) cause bronchitis, bronchiolitis and pneumonia as a result of Streptococcus pneumonia or Haemophilus Influenzae infection. In children, respiratory viruses are responsible for an enormous amount of serious LRTIs (4, 5). In addition, most upper respiratory tract infections are of viral etiology (6). Fungal infections of the lower respiratory tract are also typically caused by pathogenic dimorphic fungi (7). In addition, opportunistic fungi as Aspergillus fumigatus commonly cause pneumonia. There is an extraordinary need to better understand human respiratory tract infections, as LRTI represent one of the ten most common causes of death in the world (8).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

February

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

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UT code for WoS article

000459851000001

EID of the result in the Scopus database

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