Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071206" target="_blank" >RIV/00159816:_____/19:00071206 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/19:00109323

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.24435" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.24435</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/hbm.24435" target="_blank" >10.1002/hbm.24435</a>

Result language

angličtina

Original language name

Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort

Original language description

Depression is the leading cause of years lost due to disability worldwide. Still, the mechanisms underlying its development are not well understood. This study aimed to evaluate white-matter properties associated with depressive symptomatology in young adulthood and their developmental origins. Diffusion tensor imaging and assessment of depressive symptomatology were conducted in 128 young adults (47% male, age 23-24) from a prenatal birth cohort (European Longitudinal Study of Pregnancy and Childhood). For a subset of these individuals, the database included information on prenatal stress (n = 93) and depressive symptoms during adolescence (assessed repeatedly at age 15 and 19). Depressive symptoms in young adulthood were associated with lower fractional anisotropy in the left and right cingulum and higher fractional anisotropy in the right corticospinal tract and superior longitudinal fasciculus. Further analyses revealed that prenatal stress and depressive symptomatology during adolescence were independent predictors of altered white-matter properties in the cingulum in young adulthood. We conclude that typically developing young adults with more depressive symptoms already exhibit tract-specific alterations in white-matter properties and that prenatal stress and depressive symptomatology during adolescence might contribute to their development.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Human Brain Mapping

ISSN

1065-9471

e-ISSN

—

Volume of the periodical

40

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1155-1163

UT code for WoS article

000459470400008

EID of the result in the Scopus database

—