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Generation of two Duchenne muscular dystrophy patient-specific induced pluripotent stem cell lines DMD02 and DMD03 (MUNIi001-A and MUNIi003-A)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071213" target="_blank" >RIV/00159816:_____/19:00071213 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/19:00111317 RIV/65269705:_____/19:00071213

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S1873506119301928?via%3Dihub#gts0015" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1873506119301928?via%3Dihub#gts0015</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.scr.2019.101562" target="_blank" >10.1016/j.scr.2019.101562</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Generation of two Duchenne muscular dystrophy patient-specific induced pluripotent stem cell lines DMD02 and DMD03 (MUNIi001-A and MUNIi003-A)

  • Original language description

    Duchenne muscular dystrophy (DMD) affects 1:3500-5000 newborn boys and manifests with progressive skeletal muscle wasting, respiratory failure and eventual heart failure. Symptoms show different onset from patients&apos; childhood to the second decade of age. We reprogrammed fibroblasts from two independent DMD patients with a complete loss of dystrophin expression, carrying deletions of exons 45-50 and 48-50. The resulting hiPSCs show expression of pluripotency markers (NANOG, OCT4, SSEA4), differentiation capacity into all three germ layers, normal karyotype, genetic identity to the originating parental fibroblasts and the patient-specific dystrophin mutation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Stem Cell Research

  • ISSN

    1873-5061

  • e-ISSN

  • Volume of the periodical

    40

  • Issue of the periodical within the volume

    OCT 2019

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    5

  • Pages from-to

    101562

  • UT code for WoS article

    000491224500042

  • EID of the result in the Scopus database

    2-s2.0-85072226988