Generation of two Duchenne muscular dystrophy patient-specific induced pluripotent stem cell lines DMD02 and DMD03 (MUNIi001-A and MUNIi003-A)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071213" target="_blank" >RIV/00159816:_____/19:00071213 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00111317 RIV/65269705:_____/19:00071213
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1873506119301928?via%3Dihub#gts0015" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1873506119301928?via%3Dihub#gts0015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.scr.2019.101562" target="_blank" >10.1016/j.scr.2019.101562</a>
Alternative languages
Result language
angličtina
Original language name
Generation of two Duchenne muscular dystrophy patient-specific induced pluripotent stem cell lines DMD02 and DMD03 (MUNIi001-A and MUNIi003-A)
Original language description
Duchenne muscular dystrophy (DMD) affects 1:3500-5000 newborn boys and manifests with progressive skeletal muscle wasting, respiratory failure and eventual heart failure. Symptoms show different onset from patients' childhood to the second decade of age. We reprogrammed fibroblasts from two independent DMD patients with a complete loss of dystrophin expression, carrying deletions of exons 45-50 and 48-50. The resulting hiPSCs show expression of pluripotency markers (NANOG, OCT4, SSEA4), differentiation capacity into all three germ layers, normal karyotype, genetic identity to the originating parental fibroblasts and the patient-specific dystrophin mutation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cell Research
ISSN
1873-5061
e-ISSN
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Volume of the periodical
40
Issue of the periodical within the volume
OCT 2019
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
101562
UT code for WoS article
000491224500042
EID of the result in the Scopus database
2-s2.0-85072226988