Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071341" target="_blank" >RIV/00159816:_____/19:00071341 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00111747

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs10792-018-01063-8" target="_blank" >https://link.springer.com/article/10.1007%2Fs10792-018-01063-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10792-018-01063-8" target="_blank" >10.1007/s10792-018-01063-8</a>

Result language

angličtina

Original language name

Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy

Original language description

PurposeTo study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR). MethodsThis is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included. Ellipsoid zone disruption was assessed using spectral-domain optical coherence tomography. Serum ionic calcium and HbA1c were measured using standard protocol. Patient data from cases were divided into two groups according to their HbA1c levels: group 1 (HbA1c&lt;7, n=26) and group 2 (HbA1c&gt;7, n=37). Data were analyzed statistically.ResultsMean ionic calcium levels in group 1 and group 2 were 1.1310.073 mmol/dL and 1.170 +/- 0.070 mmol/dL, respectively. In group 1, 11 out of 26 had EZ disruption (42.3%). Similarly, in group 2, 29 out of 37 had EZ disruption (78.4%). On logistic regression analysis, as compared to group 1, ellipsoid zone disruption was found to be positively associated with serum ionic calcium (p=0.01) in group 2 cases.Conclusionp id=ParIncreased levels of serum ionic calcium are associated with increased EZ disruption in patients with HbA1c&gt;7 in DR.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30207 - Ophthalmology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

INTERNATIONAL OPHTHALMOLOGY

ISSN

0165-5701

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

2237-2243

UT code for WoS article

000491942400011

EID of the result in the Scopus database

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