Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00072912" target="_blank" >RIV/00159816:_____/20:00072912 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/20:00013017
Result on the web
<a href="https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.5MIR0420-055R" target="_blank" >https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.5MIR0420-055R</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/JLB.5MIR0420-055R" target="_blank" >10.1002/JLB.5MIR0420-055R</a>

Result language
angličtina
Original language name
Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy
Original language description
IL-2 was initially characterized as a T cell growth factor in the 1970s, and has been studied intensively ever since. Decades of research have revealed multiple and diverse roles for this potent cytokine, indicating a unique linking role between adaptive and innate arms of the immune system. Here, we review the literature showing that IL-2 is expressed in a plethora of cell types across the immune system, where it has indispensable functions in orchestrating cellular interactions and shaping the nature and magnitude of immune responses. Emerging from the basic research that has revealed the molecular mechanisms and the complexity of the biologic actions of IL-2, several immunotherapeutic approaches have now focused on manipulating the levels of this cytokine in patients. These strategies range from inhibition of IL-2 to achieve immunosuppression, to the application of IL-2 as a vaccine adjuvant and in cancer therapies. This review will systematically summarize the major findings in the field and identify key areas requiring further research in order to realize the potential of IL-2 in the treatment of human diseases.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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