Neuropsychiatric symptoms as early manifestation of Alzheimer's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00072958" target="_blank" >RIV/00159816:_____/20:00072958 - isvavai.cz</a>

Result on the web

<a href="https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2020-1-4/neuropsychiatric-symp-toms-as-early-manifestation-of-alzheimer-s-dis-ease-121153?hl=cs" target="_blank" >https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2020-1-4/neuropsychiatric-symp-toms-as-early-manifestation-of-alzheimer-s-dis-ease-121153?hl=cs</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn202064" target="_blank" >10.14735/amcsnn202064</a>

Result language

čeština

Original language name

Neuropsychiatric symptoms as early manifestation of Alzheimer's disease

Original language description

Aim: Neuropsychiatric symptoms (NPS) are a heterogeneous group of changes in personality and behavior that can be observed already in early stages of Alzheimer&apos;s disease (AD). Mild behavioral impairment (MBI) is a newly developed diagnostic category describing persistent changes in personality and behavior starting later in life. Based on these criteria, a new measure, the Mild Behavioral Impairment Checklist (MBI-C) has been developed, aimed at detecting NPS in early stages of AD. The aim of this study is to present the newly adapted Czech version of the MBI-C and to explore the presence of NPS in a pilot group of patients. Patients and methods: The original MBI-C has been adapted to Czech and administered to close informants of 188 patients. The patients were divided according to the results of a complex neuropsychological, neurological examination and brain imaging into 3 groups: cognitively normal (N = 69), amnestic mild cognitive impairment (aMCI; N = 87) and dementia due to AD (N = 32). Results: Patients with aMCI expressed in the MBI-C significantly more severe score compared to cognitively normal subjects and less severe compared to dementia patients. The differences were observed mainly in affective, motivation and impulse control domains. Conclusion: The Czech version of the MBI-C detects the presence of NPS even before the onset of dementia syndrome and is useful in clinical practice.

Czech name

Neuropsychiatric symptoms as early manifestation of Alzheimer's disease

Czech description

Aim: Neuropsychiatric symptoms (NPS) are a heterogeneous group of changes in personality and behavior that can be observed already in early stages of Alzheimer&apos;s disease (AD). Mild behavioral impairment (MBI) is a newly developed diagnostic category describing persistent changes in personality and behavior starting later in life. Based on these criteria, a new measure, the Mild Behavioral Impairment Checklist (MBI-C) has been developed, aimed at detecting NPS in early stages of AD. The aim of this study is to present the newly adapted Czech version of the MBI-C and to explore the presence of NPS in a pilot group of patients. Patients and methods: The original MBI-C has been adapted to Czech and administered to close informants of 188 patients. The patients were divided according to the results of a complex neuropsychological, neurological examination and brain imaging into 3 groups: cognitively normal (N = 69), amnestic mild cognitive impairment (aMCI; N = 87) and dementia due to AD (N = 32). Results: Patients with aMCI expressed in the MBI-C significantly more severe score compared to cognitively normal subjects and less severe compared to dementia patients. The differences were observed mainly in affective, motivation and impulse control domains. Conclusion: The Czech version of the MBI-C detects the presence of NPS even before the onset of dementia syndrome and is useful in clinical practice.

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

—

Volume of the periodical

83

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

64-72

UT code for WoS article

000514084800009

EID of the result in the Scopus database

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