Associations between high triglycerides and arterial stiffness in a population-based sample: Kardiovize Brno 2030 study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00072997" target="_blank" >RIV/00159816:_____/20:00072997 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/20:00116193

Result on the web

<a href="https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01345-0" target="_blank" >https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01345-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12944-020-01345-0" target="_blank" >10.1186/s12944-020-01345-0</a>

Result language

angličtina

Original language name

Associations between high triglycerides and arterial stiffness in a population-based sample: Kardiovize Brno 2030 study

Original language description

Background The term arterial stiffness (ArSt) describes structural changes in arterial wall related to the loss of elasticity and is known as an independent predictor of cardiovascular diseases (CVD). The evidence relating to ArSt and triglycerides (TG) shows contradictory results. This paper means to survey the association between high TG and ArSt, utilizing the cardio-ankle vascular index (CAVI). Methods Subjects aged between 25 and 64 years from a random population-based sample were evaluated between 2013 and 2016. Data from questionnaires, blood pressure, anthropometric measures, and blood samples were collected and analyzed. CAVI was measured using VaSera VS-1500 N devise. Subjects with a history of CVD or chronic renal disease were excluded. Results One thousand nine hundred thirty-four participants, 44.7% of males, were included. The median age was 48 (Interquartile Range [IQR] 19) years, TG levels were 1.05 (0.793) mmol/L, and CAVI 7.24 (1.43) points. Prevalence of high CAVI was 10.0% (14.5% in males and 6.4% in females;P &lt; 0.001) and prevalence of hypertriglyceridemia was 20.2% (29.2% in males and 13% in females,P &lt; 0.001). The correlation between TG and CAVI was 0.136 (P &lt; 0.001). High CAVI values were more prevalent among participants with metabolic syndrome (MetS), high blood pressure, dysglycemia, abdominal obesity, high LDL-cholesterol (LDL-c), and high total cholesterol. Using binary regression analysis, high TG were associated with high CAVI, even after adjustment for other MetS components, age, gender, smoking status, LDL-c, and statin treatment (beta = 0.474, OR = 1.607, 95% CI = 1.063-2.429,P = 0.024). Conclusion TG levels were correlated with ArSt, measured as CAVI. High TG was associated with high CAVI independent of multiple cardiometabolic risk factors. Awareness of the risks and targeted treatment of hypertriglyceridemia could further benefit in reducing the prevalence of CVD and events.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

LIPIDS IN HEALTH AND DISEASE

ISSN

1476-511X

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

000553306200001

EID of the result in the Scopus database

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