Orientation selective deep brain stimulation of the subthalamic nucleus in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073060" target="_blank" >RIV/00159816:_____/20:00073060 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/20:00115580

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1053811920302378?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1053811920302378?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neuroimage.2020.116750" target="_blank" >10.1016/j.neuroimage.2020.116750</a>

Result language

angličtina

Original language name

Orientation selective deep brain stimulation of the subthalamic nucleus in rats

Original language description

Deep brain stimulation (DBS) has become an important tool in the management of a wide spectrum of diseases in neurology and psychiatry. Target selection is a vital aspect of DBS so that only the desired areas are stimulated. Segmented leads and current steering have been shown to be promising additions to DBS technology enabling better control of the stimulating electric field. Recently introduced orientation selective DBS (OS-DBS) is a related development permitting sensitization of the stimulus to axonal pathways with different orientations by freely controlling the primary direction of the electric field using multiple contacts. Here, we used OS-DBS to stimulate the subthalamic nucleus (STN) in healthy rats while simultaneously monitoring the induced brain activity with fMRI. Maximal activation of the sensorimotor and basal ganglia-thalamocortical networks was observed when the electric field was aligned mediolaterally in the STN pointing in the lateral direction, while no cortical activation was observed with the electric field pointing medially to the opposite direction. Such findings are consistent with mediolateral main direction of the STN fibers, as seen with high resolution diffusion imaging and histology. The asymmetry of the OS-DBS dipolar field distribution using three contacts along with the potential stimulation of the internal capsule, are also discussed. We conclude that OS-DBS offers an additional degree of flexibility for optimization of DBS of the STN which may enable a better treatment response.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NeuroImage

ISSN

1053-8119

e-ISSN

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Volume of the periodical

213

Issue of the periodical within the volume

JUN 2020

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

116750

UT code for WoS article

000525321000025

EID of the result in the Scopus database

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