Differences in monocyte subsets are associated with short-term survival in patients with septic shock

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073521" target="_blank" >RIV/00159816:_____/20:00073521 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/20:00116527
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/jcmm.15791" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jcmm.15791</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jcmm.15791" target="_blank" >10.1111/jcmm.15791</a>

Result language
angličtina
Original language name
Differences in monocyte subsets are associated with short-term survival in patients with septic shock
Original language description
Sepsis is characterized by dynamic changes of the immune system resulting in deregulated inflammation and failure of homoeostasis and can escalate to septic shock. Circulating monocytes and other innate immune cells are among the first ones to recognize and clear pathogens. Monocytes have an important role in sepsis and septic shock and have been studied as potential diagnostic markers. In total, forty-two patients with septic shock were recruited and blood samples obtained within first 12 hours of ICU admission. We showed that frequency of classical and intermediate monocytes assessed at the time of admission to the intensive care unit are significantly distinct in patients with septic shock who survived longer that five days from those who died. These parameters correlate significantly with differences in serum levels of inflammatory cytokines MCP-1, IL-6, IL-8, IL-10, and IL-18, and with the proportion of helper and cytotoxic T cells. The described changes in frequency of monocyte subsets and their activation status may predict short-term septic shock survival and help with fast identification of the group of vulnerable patients, who may profit from tailored therapy.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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