Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00074027" target="_blank" >RIV/00159816:_____/20:00074027 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/20:00115980

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2213158220300711?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2213158220300711?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nicl.2020.102234" target="_blank" >10.1016/j.nicl.2020.102234</a>

Result language

angličtina

Original language name

Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis

Original language description

Even though MRI visualization of white matter lesions is pivotal for the diagnosis and management of multiple sclerosis (MS), the issue of detecting diffuse brain tissue damage beyond the apparent T2-hyperintense lesions continues to spark considerable interest. Motivated by the notion that rotating frame MRI methods are sensitive to slow motional regimes critical for tissue characterization, here we utilized novel imaging protocols of rotating frame MRI on a clinical 3 Tesla platform, including adiabatic longitudinal, T1 rho, and transverse, T2 rho, relaxation methods, and Relaxation Along a Fictitious Field (RAFF) in the rotating frame of rank 4 (RAFF4), in 10 relapsing-remitting multiple sclerosis patients and 10 sex- and age-matched healthy controls. T1 rho, T2 rho and RAFF4 relaxograms extracted from the whole white matter exhibited a significant shift towards longer relaxation time constants in MS patients as compared to controls. T1 rho and RAFF4 detected alterations even when considering only regions of normally appearing white matter (NAWM), while other MRI metrics such as T1w/T2w ratio and diffusion tensor imaging measures failed to find group differences. In addition, RAFF4, T2 rho and, to a lesser extent, T1 rho showed differences in subcortical grey matter structures, mainly hippocampus, whereas no functional changes in this region were detected in resting-state functional MRI metrics. We conclude that rotating frame MRI techniques are exceptionally sensitive methods for the detection of subtle abnormalities not only in NAWM, but also in deep grey matter in MS, where they surpass even highly sensitive measures of functional changes, which are often suggested to precede detectable structural alterations. Such abnormalities are consistent with a wide spectrum of different, but interconnected pathological features of MS, including the loss of neuronal cells and their axons, decreased levels of myelin even in NAWM, and altered iron content.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NeuroImage-Clinical

ISSN

2213-1582

e-ISSN

—

Volume of the periodical

26

Issue of the periodical within the volume

2020

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

102234

UT code for WoS article

000533149400052

EID of the result in the Scopus database

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