The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074440" target="_blank" >RIV/00159816:_____/21:00074440 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/21:10416906 RIV/00216208:11120/21:43920725 RIV/00216208:11130/21:10416906 RIV/00216208:11140/21:10416906 and 6 more

Result on the web

<a href="https://academic.oup.com/jac/article-abstract/76/1/55/5942696?redirectedFrom=fulltext" target="_blank" >https://academic.oup.com/jac/article-abstract/76/1/55/5942696?redirectedFrom=fulltext</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jac/dkaa404" target="_blank" >10.1093/jac/dkaa404</a>

Result language

angličtina

Original language name

The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic

Original language description

Objectives: To gain data on the current molecular epidemiology and resistance of MRSA in the Czech Republic. Methods: Between September 2017 and January 2018, a total of 441 single-patient MRSA isolates were collected from 11 Czech hospitals and analysed by spa typing, SCCmec typing, antibiotic susceptibility testing, detection of the PVL toxin and the arcA gene. Results: Of all MRSA isolates, 81.41% (n = 359) belonged to the CC5-MRSA clone represented by the spa types t003 (n = 136), t586 (n = 92), t014 (n = 81), t002 (n = 20) and other spa types (n = 30); a majority of the CC5 isolates (n = 348, 96.94%) carried SCCmec type II. The occurrence of CC5-MRSA was more Likely in older inpatients and associated with a healthcare origin (P&lt; 0.001). The CC5-MRSA isolates were resistant to more antimicrobial drugs compared with the other MRSAs (P&lt; 0.001). Interestingly, t586 was detected in blood samples more often than the other spa types and, contrary to other spa types belonging to CC5-MRSA, t586 was not associated with patients of advanced age. Other frequently found Lineages were CC8 (n = 17), CC398 (n = 11) and CC59 (n = 10). The presence of the PVL was detected in 8.62% (n = 38) of the MRSA isolates. Conclusions: The healthcare-associated CC5-MRSA-II Lineage (t003, t586, t014) was found to be predominant in the Czech Republic. t586 is a newly emerging spa type in the Czech Republic, yet reported rarely in other countries. Our observations stress the need for MRSA surveillance in the Czech Republic in order to monitor changes in MRSA epidemiology.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/NV17-30460A" target="_blank" >NV17-30460A: Molecular characterization of adaptive antibiotic resistance and tolerance mechanisms of Staphylococcus aureus strains causing chronic infections</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of antimicrobial chemotherapy

ISSN

0305-7453

e-ISSN

—

Volume of the periodical

76

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

55-64

UT code for WoS article

000620811500006

EID of the result in the Scopus database

2-s2.0-85098466887