TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074462" target="_blank" >RIV/00159816:_____/21:00074462 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/21:00074462 RIV/00064203:_____/21:10429284 RIV/00216208:11130/21:10429284
Result on the web
<a href="https://www.nature.com/articles/s41698-021-00178-z" target="_blank" >https://www.nature.com/articles/s41698-021-00178-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41698-021-00178-z" target="_blank" >10.1038/s41698-021-00178-z</a>
Alternative languages
Result language
angličtina
Original language name
TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE study
Original language description
In children with cancer, the heterogeneity in ototoxicity occurrence after similar treatment suggests a role for genetic susceptibility. Using a genome-wide association study (GWAS) approach, we identified a genetic variant in TCERG1L (rs893507) to be associated with hearing loss in 390 non-cranial irradiated, cisplatin-treated children with cancer. These results were replicated in two independent, similarly treated cohorts (n = 192 and 188, respectively) (combined cohort: P= 5.3 x 10(-10), OR 3.11, 95% CI 2.2-4.5). Modulating TCERG1L expression in cultured human cells revealed significantly altered cellular responses to cisplatin-induced cytokine secretion and toxicity. These results contribute to insights into the genetic and pathophysiological basis of cisplatin-induced ototoxicity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/7E13061" target="_blank" >7E13061: PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
npj Precision Oncology
ISSN
2397-768X
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
64
UT code for WoS article
000673531000001
EID of the result in the Scopus database
2-s2.0-85117051914