Memory outcomes of temporal lobe surgery in adults aged over 45 years

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074681" target="_blank" >RIV/00159816:_____/21:00074681 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00120098

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/ane.13427" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/ane.13427</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ane.13427" target="_blank" >10.1111/ane.13427</a>

Result language

angličtina

Original language name

Memory outcomes of temporal lobe surgery in adults aged over 45 years

Original language description

Objective It is assumed that temporal lobe resection in older people is associated with worse seizure outcomes and potential postsurgical memory decline. We studied postsurgical memory development and surgical efficacy in patients over 45 years of age compared with younger patients. Methods We studied 88 patients (51 male and 37 female) after temporal lobe surgery, which involved hippocampal resection. The patients were evaluated before surgery and in the first (72 patients) and/or third (57 patients) postsurgical year. The Wechsler Memory Scale III test was performed to evaluate the MQ postsurgical development. Engel&apos;s classification was used to evaluate the postsurgical seizure outcome. Results The presurgical MQ (median 88) in &gt;= 45 years age group was significantly lower than in both younger groups (median MQ = 100 for &lt;= 30 years age group, p = 0.002; median MQ = 107 for 31-44 years age group, p = 0.002). Three years after the surgery, the MQ decreased significantly in &lt;= 30 years age group (p = 0.012), while only non-significant MQ decline was observed in both older groups. We found no significant impact of age on the surgical outcome. Conclusion Higher age at the time of surgery does not significantly increase the risk for postsurgical memory decline; however, older patients are more likely to have lowered presurgical MQ. We did not find significant differences in the impact of surgery on seizure outcome among the age groups. Epilepsy surgery appears to be a safe and effective method in the age over 45 years even though an earlier surgery should be preferred.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta neurologica Scandinavica

ISSN

0001-6314

e-ISSN

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Volume of the periodical

144

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

81-91

UT code for WoS article

000641828400001

EID of the result in the Scopus database

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