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Association of the CD14-260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074953" target="_blank" >RIV/00159816:_____/21:00074953 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064165:_____/22:10429306 RIV/00216208:11110/22:10429306 RIV/00216224:14110/22:00124966

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/ipd.12847" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/ipd.12847</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/ipd.12847" target="_blank" >10.1111/ipd.12847</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Association of the CD14-260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis

  • Original language description

    Background Plaque-induced gingivitis is the most prevalent periodontal disease associated with pathogenic biofilms. The host immune system responds to pathogens through pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and their co-receptor CD14. Aim This study investigated the association between the functional polymorphism in the CD14 gene and the dental plaque microbiota in children with gingivitis. Design A total of 590 unrelated children (307 with plaque-induced gingivitis and 283 controls, aged 13-15 years) were enrolled in this case-control study. Dental plaque was processed using a ParoCheck(R) 20 detection kit. The CD14 -260C/T (rs2569190) polymorphism was determined with the PCR-RFLP method. Results Gingivitis was detected in 64.2% of boys, but only in 35.8% of girls (P &lt; .001). Children with gingivitis had a significantly higher occurrence of dental caries (P &lt; .001). No significant differences in the CD14 -260C/T allele and genotype distribution among individuals with or without gingivitis in the whole cohort were found. Children with gingivitis and P gingivalis, however, were significantly more frequent carriers of the CT and TT genotypes than children with gingivitis without P gingivalis or healthy controls (P &lt; .05). Conclusions The CD14 -260C/T polymorphism acts in cooperation with P gingivalis to trigger plaque-induced gingivitis in Czech children.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30208 - Dentistry, oral surgery and medicine

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Paediatric Dentistry

  • ISSN

    0960-7439

  • e-ISSN

  • Volume of the periodical

    32

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    223-231

  • UT code for WoS article

    000661667900001

  • EID of the result in the Scopus database