Association of the CD14-260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074953" target="_blank" >RIV/00159816:_____/21:00074953 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/22:10429306 RIV/00216208:11110/22:10429306 RIV/00216224:14110/22:00124966
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/ipd.12847" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/ipd.12847</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ipd.12847" target="_blank" >10.1111/ipd.12847</a>
Alternative languages
Result language
angličtina
Original language name
Association of the CD14-260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis
Original language description
Background Plaque-induced gingivitis is the most prevalent periodontal disease associated with pathogenic biofilms. The host immune system responds to pathogens through pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and their co-receptor CD14. Aim This study investigated the association between the functional polymorphism in the CD14 gene and the dental plaque microbiota in children with gingivitis. Design A total of 590 unrelated children (307 with plaque-induced gingivitis and 283 controls, aged 13-15 years) were enrolled in this case-control study. Dental plaque was processed using a ParoCheck(R) 20 detection kit. The CD14 -260C/T (rs2569190) polymorphism was determined with the PCR-RFLP method. Results Gingivitis was detected in 64.2% of boys, but only in 35.8% of girls (P < .001). Children with gingivitis had a significantly higher occurrence of dental caries (P < .001). No significant differences in the CD14 -260C/T allele and genotype distribution among individuals with or without gingivitis in the whole cohort were found. Children with gingivitis and P gingivalis, however, were significantly more frequent carriers of the CT and TT genotypes than children with gingivitis without P gingivalis or healthy controls (P < .05). Conclusions The CD14 -260C/T polymorphism acts in cooperation with P gingivalis to trigger plaque-induced gingivitis in Czech children.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30208 - Dentistry, oral surgery and medicine
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Paediatric Dentistry
ISSN
0960-7439
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
223-231
UT code for WoS article
000661667900001
EID of the result in the Scopus database
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