Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075027" target="_blank" >RIV/00159816:_____/21:00075027 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s42255-021-00469-6" target="_blank" >https://www.nature.com/articles/s42255-021-00469-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s42255-021-00469-6" target="_blank" >10.1038/s42255-021-00469-6</a>

Result language

angličtina

Original language name

Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan

Original language description

While on a high-fat, high-calorie diet, a monthly cycle of 5 days of a fasting-mimicking diet can prevent obesity and related detrimental effects on cardiometabolic health and lifespan in mice. Diet-induced obesity is a major risk factor for metabolic syndrome, diabetes and cardiovascular disease. Here, we show that a 5-d fasting-mimicking diet (FMD), administered every 4 weeks for a period of 2 years, ameliorates the detrimental changes caused by consumption of a high-fat, high-calorie diet (HFCD) in female mice. We demonstrate that monthly FMD cycles inhibit HFCD-mediated obesity by reducing the accumulation of visceral and subcutaneous fat without causing loss of lean body mass. FMD cycles increase cardiac vascularity and function and resistance to cardiotoxins, prevent HFCD-dependent hyperglycaemia, hypercholesterolaemia and hyperleptinaemia and ameliorate impaired glucose and insulin tolerance. The effect of monthly FMD cycles on gene expression associated with mitochondrial metabolism and biogenesis in adipocytes and the sustained ketogenesis in HFCD-fed mice indicate a role for fat cell reprogramming in obesity prevention. These effects of an FMD on adiposity and cardiac ageing could explain the protection from HFCD-dependent early mortality.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NATURE METABOLISM

ISSN

2522-5812

e-ISSN

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Volume of the periodical

3

Issue of the periodical within the volume

10

Country of publishing house

DE - GERMANY

Number of pages

25

Pages from-to

1342-"+"

UT code for WoS article

000707307800005

EID of the result in the Scopus database

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