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Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075034" target="_blank" >RIV/00159816:_____/21:00075034 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/21:00075034 RIV/00064203:_____/21:10415919 RIV/00216208:11130/21:10415919 RIV/00216224:14110/21:00124151

  • Result on the web

    <a href="https://bjo.bmj.com/content/105/10/1435" target="_blank" >https://bjo.bmj.com/content/105/10/1435</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1136/bjophthalmol-2020-316613" target="_blank" >10.1136/bjophthalmol-2020-316613</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries

  • Original language description

    Background The travel distance from home to a treatment centre, which may impact the stage at diagnosis, has not been investigated for retinoblastoma, the most common childhood eye cancer. We aimed to investigate the travel burden and its impact on clinical presentation in a large sample of patients with retinoblastoma from Africa and Europe. Methods A cross-sectional analysis including 518 treatment-naive patients with retinoblastoma residing in 40 European countries and 1024 treatment-naive patients with retinoblastoma residing in 43 African countries. Results Capture rate was 42.2% of expected patients from Africa and 108.8% from Europe. African patients were older (95% CI -12.4 to -5.4, p&lt;0.001), had fewer cases of familial retinoblastoma (95% CI 2.0 to 5.3, p&lt;0.001) and presented with more advanced disease (95% CI 6.0 to 9.8, p&lt;0.001); 43.4% and 15.4% of Africans had extraocular retinoblastoma and distant metastasis at the time of diagnosis, respectively, compared to 2.9% and 1.0% of the Europeans. To reach a retinoblastoma centre, European patients travelled 421.8 km compared to Africans who travelled 185.7 km (p&lt;0.001). On regression analysis, lower-national income level, African residence and older age (p&lt;0.001), but not travel distance (p=0.19), were risk factors for advanced disease. Conclusions Fewer than half the expected number of patients with retinoblastoma presented to African referral centres in 2017, suggesting poor awareness or other barriers to access. Despite the relatively shorter distance travelled by African patients, they presented with later-stage disease. Health education about retinoblastoma is needed for carers and health workers in Africa in order to increase capture rate and promote early referral.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30207 - Ophthalmology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    British Journal of Ophthalmology

  • ISSN

    0007-1161

  • e-ISSN

  • Volume of the periodical

    105

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    1435-1443

  • UT code for WoS article

    000702446300022

  • EID of the result in the Scopus database

    2-s2.0-85091841297