Cellular pathology of the human heart in Duchenne muscular dystrophy (DMD): lessons learned from in vitro modeling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075080" target="_blank" >RIV/00159816:_____/21:00075080 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/21:00120133
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00424-021-02589-0" target="_blank" >https://link.springer.com/article/10.1007%2Fs00424-021-02589-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00424-021-02589-0" target="_blank" >10.1007/s00424-021-02589-0</a>
Alternative languages
Result language
angličtina
Original language name
Cellular pathology of the human heart in Duchenne muscular dystrophy (DMD): lessons learned from in vitro modeling
Original language description
Duchenne muscular dystrophy is a genetic disorder where an X-linked mutation in the DMD gene initiates pathogenic development caused by the absence of dystrophin protein. This impacts primarily the evolution of a functional muscle tissue resulting in muscle weakness and later severe disability in young male patients leading to an early death. Patients in the final stage develop dilated cardiomyopathy leading ultimately to cardiac or respiratory failure as the cause of death. This review discusses recent advances in modeling the DMD pathology in vitro. It describes in detail the molecular abnormalities found on the cellular and organoid levels. The in vitro pathology is compared to that found in patients. Likewise, the drawbacks and limitations of current models are discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pflügers Archiv European Journal of Physiology
ISSN
0031-6768
e-ISSN
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Volume of the periodical
473
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
1099-1115
UT code for WoS article
000665672700001
EID of the result in the Scopus database
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