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Cellular pathology of the human heart in Duchenne muscular dystrophy (DMD): lessons learned from in vitro modeling

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075080" target="_blank" >RIV/00159816:_____/21:00075080 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/21:00120133

  • Result on the web

    <a href="https://link.springer.com/article/10.1007%2Fs00424-021-02589-0" target="_blank" >https://link.springer.com/article/10.1007%2Fs00424-021-02589-0</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00424-021-02589-0" target="_blank" >10.1007/s00424-021-02589-0</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cellular pathology of the human heart in Duchenne muscular dystrophy (DMD): lessons learned from in vitro modeling

  • Original language description

    Duchenne muscular dystrophy is a genetic disorder where an X-linked mutation in the DMD gene initiates pathogenic development caused by the absence of dystrophin protein. This impacts primarily the evolution of a functional muscle tissue resulting in muscle weakness and later severe disability in young male patients leading to an early death. Patients in the final stage develop dilated cardiomyopathy leading ultimately to cardiac or respiratory failure as the cause of death. This review discusses recent advances in modeling the DMD pathology in vitro. It describes in detail the molecular abnormalities found on the cellular and organoid levels. The in vitro pathology is compared to that found in patients. Likewise, the drawbacks and limitations of current models are discussed.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30105 - Physiology (including cytology)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pflügers Archiv European Journal of Physiology

  • ISSN

    0031-6768

  • e-ISSN

  • Volume of the periodical

    473

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    17

  • Pages from-to

    1099-1115

  • UT code for WoS article

    000665672700001

  • EID of the result in the Scopus database