Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075087" target="_blank" >RIV/00159816:_____/21:00075087 - isvavai.cz</a>
Result on the web
<a href="https://www.nrronline.org/temp/NeuralRegenRes1681467-5402109_150021.pdf" target="_blank" >https://www.nrronline.org/temp/NeuralRegenRes1681467-5402109_150021.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4103/1673-5374.303007" target="_blank" >10.4103/1673-5374.303007</a>
Alternative languages
Result language
angličtina
Original language name
Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases
Original language description
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with multifactorial etiologies and pathogeneses that manifest distinct molecular mechanisms and clinical manifestations with abnormal protein dynamics and impaired bioenergetics. Mitochondrial dysfunction is emerging as an important feature in the etiopathogenesis of these age-related neurodegenerative diseases. The prevalence and incidence of these diseases is on the rise with the increasing global population and average lifespan. Although many therapeutic approaches have been tested, there are currently no effective treatment routes for the prevention or cure of these diseases. We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/EF15_003%2F0000492" target="_blank" >EF15_003/0000492: Unveiling the molecular determinants of agingto design new therapeutics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neural Regeneration Research
ISSN
1673-5374
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
8
Country of publishing house
IN - INDIA
Number of pages
16
Pages from-to
1467-1482
UT code for WoS article
000609622400003
EID of the result in the Scopus database
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