The Prevalence of Dysglycemia-Based Chronic Disease in a European Population - a New Paradigm to Address Diabetes Burden: A Kardiovize Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075104" target="_blank" >RIV/00159816:_____/21:00075104 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/21:10425453 RIV/00216208:11130/21:10425453 RIV/00216224:14110/21:00121637

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1530891X20483600?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1530891X20483600?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eprac.2020.10.003" target="_blank" >10.1016/j.eprac.2020.10.003</a>

Result language

angličtina

Original language name

The Prevalence of Dysglycemia-Based Chronic Disease in a European Population - a New Paradigm to Address Diabetes Burden: A Kardiovize Study

Original language description

Objective: To determine the prevalence rate and associated risk factors for each stage of the Dysglycemia-Based Chronic Disease (DBCD) model, which 4 distinct stages and prompts early prevention to avert Diabetes and cardiometabolic complications. Methods: Subjects between 25 and 64 years old from a random population-based sample were evaluated in Czechia from 2013 to 2014 using a cross-sectional design. DBCD stages were: stage 1 &quot;insulin resistance&quot; (inferred risk from abdominal obesity or a family history of diabetes); stage 2 &quot;prediabetes&quot;(fasting glucose between 5.6 and 6.9 mmol/L); stage 3 &quot;type 2 diabetes (T2D)&quot; (self-report of T2D or fasting glucose &gt;= 7 mmol/L); and stage 4 &quot;vascular complications&quot; (T2D with cardiovascular disease). Results: A total of 2147 subjects were included (57.8% women) with a median age of 48 years. The prevalence of each DBCD stage were as follows: 54.2% (stage 1); 10.3% (stage 2), 3.7% (stage 3); and 1.2% (stage 4). Stages 2 to 4 were more frequent in men and stage 1 in women (P &lt; .001). Using binary logistic regression analysis adjusting by age/sex, all DBCD stages were strongly associated with abnormal adiposity, hypertension, dyslipidemia, and smoking status. Subjects with lower educational levels and lower income were more likely to present DBCD. Conclusion: Using the new DBCD framework and available metrics, 69.4% of the population had DBCD, identifying far more people at risk than a simple prevalence rate for T2D (9.2% in Czechia, 2013-2014). All stages were associated with traditional cardiometabolic risk factors, implicating common pathophysiologic mechanisms and a potential for early preventive care. The social determinants of health were related with all DBCD stages in alarming proportions and will need to be further studied. (C) 2020 AACE. Published by Elsevier Inc.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Endocrine Practice

ISSN

1530-891X

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

455-462

UT code for WoS article

000644659800012

EID of the result in the Scopus database

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