Multi-pathogen infections and Alzheimer's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075140" target="_blank" >RIV/00159816:_____/21:00075140 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/21:00119789

Result on the web

<a href="https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-021-01520-7" target="_blank" >https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-021-01520-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12934-021-01520-7" target="_blank" >10.1186/s12934-021-01520-7</a>

Result language

angličtina

Original language name

Multi-pathogen infections and Alzheimer's disease

Original language description

Alzheimer&apos;s disease (AD) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-beta peptide and hyperphosphorylation of tau proteins in the brain. Despite extensive research on the amyloid-based mechanism of AD pathogenesis, the underlying cause of AD is not fully understood. No disease-modifying therapies currently exist, and numerous clinical trials have failed to demonstrate any benefits. The recent discovery that the amyloid-beta peptide has antimicrobial activities supports the possibility of an infectious aetiology of AD and suggests that amyloid-beta plaque formation might be induced by infection. AD patients have a weakened blood-brain barrier and immune system and are thus at elevated risk of microbial infections. Such infections can cause chronic neuroinflammation, production of the antimicrobial amyloid-beta peptide, and neurodegeneration. Various pathogens, including viruses, bacteria, fungi, and parasites have been associated with AD. Most research in this area has focused on individual pathogens, with herpesviruses and periodontal bacteria being most frequently implicated. The purpose of this review is to highlight the potential role of multi-pathogen infections in AD. Recognition of the potential coexistence of multiple pathogens and biofilms in AD&apos;s aetiology may stimulate the development of novel approaches to its diagnosis and treatment. Multiple diagnostic tests could be applied simultaneously to detect major pathogens, followed by anti-microbial treatment using antiviral, antibacterial, antifungal, and anti-biofilm agents.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20801 - Environmental biotechnology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

MICROBIAL CELL FACTORIES

ISSN

1475-2859

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

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UT code for WoS article

000616106500001

EID of the result in the Scopus database

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