T-Cell Activation: Post-Infection Diagnostic Tool for COVID-19

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075142" target="_blank" >RIV/00159816:_____/21:00075142 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00122151

Result on the web

<a href="https://fb.cuni.cz/file/5943/fb2021a0003.pdf" target="_blank" >https://fb.cuni.cz/file/5943/fb2021a0003.pdf</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

T-Cell Activation: Post-Infection Diagnostic Tool for COVID-19

Original language description

COVID-19 is caused by the SARS-CoV-2 virus and has spread globally in 2020. Cellular immunity may serve as an important functional marker of the disease, especially in the asymptomatic cases. Blood samples were collected from 46 convalescent donors with a history of COVID-19 and 38 control donors. Quantification of the T-cell response upon contact with SARS-CoV-2 proteins in vitro was based on IFN-y. Significantly higher numbers of activated cells were measured in patients who underwent COVID-19. Anti-SARS-CoV-2 T cells were detected weeks after the active virus disappeared from the organism. Repeated sample collection after five months proved that the T-cell activation was weaker in time in 79 % of the patients. In the majority of cases, the CD4(+) helper T-cell subpopulation was responsible for the immune reaction. Moreover, different viral proteins triggered activation in CD4(+) helper and in CD8(+) cytotoxic T cells. Together, these findings suggest that the T-cell activation level identifies the individuals who underwent COVID-19 and may become a diagnostic tool for the disease.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia biologica (Praha)

ISSN

0015-5500

e-ISSN

—

Volume of the periodical

67

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

12

Pages from-to

16-27

UT code for WoS article

000672501500002

EID of the result in the Scopus database

—