Correlation between electromechanical parameters (NOGA XP) and changes of myocardial ischemia in patients with refractory angina

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075150" target="_blank" >RIV/00159816:_____/21:00075150 - isvavai.cz</a>

Result on the web

<a href="https://www.termedia.pl/Correlation-between-electromechanical-parameters-NOGA-XP-and-changes-of-myocardial-ischemia-in-patients-with-refractory-angina,35,45165,1,1.html" target="_blank" >https://www.termedia.pl/Correlation-between-electromechanical-parameters-NOGA-XP-and-changes-of-myocardial-ischemia-in-patients-with-refractory-angina,35,45165,1,1.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/aic.2021.109168" target="_blank" >10.5114/aic.2021.109168</a>

Result language

angličtina

Original language name

Correlation between electromechanical parameters (NOGA XP) and changes of myocardial ischemia in patients with refractory angina

Original language description

Introduction: Cell therapy has the potential to improve symptoms and clinical outcomes in refractory angina (RFA). Further analyses are needed to evaluate factors influencing its therapeutic effectiveness. Aim: Assessment of electromechanical (EM) parameters of the left ventricle (LV) and investigation of correlation between EM parameters of the myocardium and response to CD133+ cell therapy. Material and methods: Thirty patients with RFA (16 active and 14 placebo individuals) enrolled in the REGENT-VSEL trial underwent EM evaluation of the LV with intracardiac mapping system. The following parameters were analyzed: unipolar voltage (UV), bipolar voltage (BV), local linear shortening (LLS). Myocardial ischemia was evaluated with single-photon emission computed tomography (SPECT). The median value of each EM parameter was used for intra-group comparisons. Results: Global EM parameters (UV, BV, LLS) of LV in active and placebo groups were 11.28 mV, 3.58 mV, 11.12%, respectively; 13.00 mV, 3.81 mV, 11.32%, respectively. EM characteristics analyzed at global and segmental levels did not predict response to CD133+ cell therapy in patients with RFA (Global UV, BV and LLS at rest R = -0.06; R = 0.2; R = -0.1 and at stress: R = 0.07, R = 0.09, R = -0.1, respectively; Segmental UV, BV, LLS at rest R = -0.2, R = 0.03, R = -0.4 and at stress R = 0.02, R = 0.2, R = -0.2, respectively). Multiple linear regression of the treated segments showed that only pre-injection SPECT levels were significantly correlated with post-injection SPECT, either at rest or stress (p &lt; 0.05). Conclusions: Electromechanical characteristics of the left ventricle do not predict changes of myocardial perfusion by SPECT after cell therapy. Baseline SPECT results are only predictors of changes of myocardial ischemia observed at 4-month follow-up.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Postepy w Kardiologii Interwencyjnej

ISSN

1734-9338

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

3

Country of publishing house

PL - POLAND

Number of pages

9

Pages from-to

281-289

UT code for WoS article

000714943600005

EID of the result in the Scopus database

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