Validating Effect of Sulodexide in Treatment of Claudication Pain and Chronic Limb-Threatening Ischemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075874" target="_blank" >RIV/00159816:_____/21:00075874 - isvavai.cz</a>

Result on the web

<a href="https://www.walshmedicalmedia.com/open-access/validating-effect-of-sulodexide-in-treatment-of-claudication-pain-and-chronic-limbthreatening-ischemia.pdf" target="_blank" >https://www.walshmedicalmedia.com/open-access/validating-effect-of-sulodexide-in-treatment-of-claudication-pain-and-chronic-limbthreatening-ischemia.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Validating Effect of Sulodexide in Treatment of Claudication Pain and Chronic Limb-Threatening Ischemia

Original language description

Background: Peripheral arterial disease is a chronical disease which can lead to a sever quality of life reduction and in certain cases there is no indication or even possibility for revascularization and these patients are reliant on conservative therapy such as Sulodexide medication. Objective: In the retrospective study we evaluated effect of newly administrated Sulodexide therapy for patients with peripheral arterial disease both in cases of claudication pain and patients with chronic limb-threatening ischemia (CLTI). Methods: During a three year period we started Sulodexide therapy in 34 claudication and 38 CLTI cases with no contemporary revascularization procedure. Patients were followed for 4 and 8 months with claudication interval, Rutherford classification and CLTI evaluation. Results: We observed overall positive effect of Sulodexide in both groups. In claudication group there was a prolongation of average pain-free walking distance (PFWD) from 144 m at the baseline to 376 m at 4 months and 430 m at 8 months. In the second group all 38 patients started with CLTI symptoms, after 4 months 6 patients remained with CLTI and after 8 months 3 more had recurrence of CLTI. Conclusion: We observed a significant improvement both in PFWD in claudication sub-group and even in a clinical status of majority of the patients in CLTI sub-group. This effect of Sulodexide on CLTI patients was not yet thoroughly described in any available literature. According to our observations, Sulodexide seem to be a potent auxiliary therapy for patient with peripheral arterial disease even in the case CLTI.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30212 - Surgery

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Vascular Medicine &amp; Surgery

ISSN

2329-6925

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

409-415

UT code for WoS article

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EID of the result in the Scopus database

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