Prognostic value of soluble endoglin in patients with septic shock and severe COVID-19

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076256" target="_blank" >RIV/00159816:_____/22:00076256 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/22:00013451 RIV/65269705:_____/22:00076256 RIV/00216224:14110/22:00129697

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fmed.2022.972040/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fmed.2022.972040/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmed.2022.972040" target="_blank" >10.3389/fmed.2022.972040</a>

Result language

angličtina

Original language name

Prognostic value of soluble endoglin in patients with septic shock and severe COVID-19

Original language description

Sepsis is a clinical syndrome characterized by a dysregulated response to infection. It represents a leading cause of mortality in ICU patients worldwide. Although sepsis is in the point of interest of research for several decades, its clinical management and patient survival are improving slowly. Monitoring of the biomarkers and their combinations could help in early diagnosis, estimation of prognosis and patient&apos;s stratification and response to the treatment. Circulating soluble endoglin (sEng) is the cleaved extracellular part of transmembrane glycoprotein endoglin. As a biomarker, sEng has been tested in several pathologic conditions where its elevation was associated with endothelial dysfunction. In this study we have tested the ability of sEng to predict mortality and its correlation with other clinical characteristics in the cohort of septic shock patients (n = 37) and patients with severe COVID-19 (n = 40). In patients with COVID-19 sEng did not predict mortality or correlate with markers of organ dysfunction. In contrast, in septic shock the level of sEng was significantly higher in patients with early mortality (p = 0.019; AUC = 0.801). Moreover, sEng levels correlated with signs of circulatory failure (required dose of noradrenalin and lactate levels; p = 0.002 and 0.016, respectively). The predominant clinical problem in patients with COVID-19 was ARDS, and although they often showed signs of other organ dysfunction, circulatory failure was exceptional. This potentially explains the difference between sEng levels in COVID-19 and septic shock. In conclusion, we have confirmed that sEng may reflect the extent of the circulatory failure in septic shock patients and thus could be potentially used for the early identification of patients with the highest degree of endothelial dysfunction who would benefit from endothelium-targeted individualized therapy.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30218 - General and internal medicine

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FRONTIERS IN MEDICINE

ISSN

2296-858X

e-ISSN

2296-858X

Volume of the periodical

9

Issue of the periodical within the volume

August

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

972040

UT code for WoS article

000854438500001

EID of the result in the Scopus database

—