Blood-Brain Barrier Alterations and Edema Formation in Different Brain Mass Lesions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076264" target="_blank" >RIV/00159816:_____/22:00076264 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/22:00127602
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fncel.2022.922181/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fncel.2022.922181/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fncel.2022.922181" target="_blank" >10.3389/fncel.2022.922181</a>
Alternative languages
Result language
angličtina
Original language name
Blood-Brain Barrier Alterations and Edema Formation in Different Brain Mass Lesions
Original language description
Differential diagnosis of brain lesion pathologies is complex, but it is nevertheless crucial for appropriate clinical management. Advanced imaging methods, including diffusion-weighted imaging and apparent diffusion coefficient, can help discriminate between brain mass lesions such as glioblastoma, brain metastasis, brain abscesses as well as brain lymphomas. These pathologies are characterized by blood-brain barrier alterations and have been extensively studied. However, the changes in the blood-brain barrier that are observed around brain pathologies and that contribute to the development of vasogenic brain edema are not well described. Some infiltrative brain pathologies such as glioblastoma are characterized by glioma cell infiltration in the brain tissue around the tumor mass and thus affect the nature of the vasogenic edema. Interestingly, a common feature of primary and secondary brain tumors or tumor-like brain lesions characterized by vasogenic brain edema is the formation of various molecules that lead to alterations of tight junctions and result in blood-brain barrier damage. The resulting vasogenic edema, especially blood-brain barrier disruption, can be visualized using advanced magnetic resonance imaging techniques, such as diffusion-weighted imaging and apparent diffusion coefficient. This review presents a comprehensive overview of blood-brain barrier changes contributing to the development of vasogenic brain edema around glioblastoma, brain metastases, lymphomas, and abscesses.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/LTC20027" target="_blank" >LTC20027: Mapping of glioma heterogeneity and infiltration extend by MR imaging biomarkers</a><br>
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cellular Neuroscience
ISSN
1662-5102
e-ISSN
1662-5102
Volume of the periodical
16
Issue of the periodical within the volume
922181
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
nestrankovano
UT code for WoS article
000841737900001
EID of the result in the Scopus database
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