Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076326" target="_blank" >RIV/00159816:_____/22:00076326 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/22:00125326

Result on the web

<a href="https://link.springer.com/article/10.1007/s00702-022-02466-9" target="_blank" >https://link.springer.com/article/10.1007/s00702-022-02466-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-022-02466-9" target="_blank" >10.1007/s00702-022-02466-9</a>

Result language

angličtina

Original language name

Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls

Original language description

The vertex has been used as a suitable control stimulation site in repetitive transcranial magnetic stimulation studies. The objectives of this study are (1) to assess cognitive performance (CP) after theta burst stimulation (TBS); (2) to evaluate whether clinically relevant cortical areas might be reached by vertex stimulation and how that might influence CP. Twenty young healthy subjects performed a cognitive task prior to and immediately after intermittent TBS (iTBS) and continuous TBS (cTBS) of two active cortical stimulation sites and the vertex. We used the Wilcoxon signed-rank test to compare the pre- and post-stimulation reaction times (RTs) and a mixed ANOVA analysis to evaluate the effect of the stimulation on changes in RTs. A three-dimensional finite-element model (FEM) was used to calculate the vertex TBS-induced electrical field (E-field) in the adjacent regions of interest (ROIs). Correlation analyses were performed between E-fields in the ROIs and cognitive outcomes. We found a significant effect only of the stimulation time factor (F (1,12) = 65.37, p &lt; 0.001) on RT shortening, with no superiority of the active site stimulation compared to the vertex stimulation. In 73.5% of vertex TBS sessions, a significant E-field was induced in at least one ROI. We found a negative association between the magnitude of the iTBS-induced E-fields and RT changes (R = - 0.54, p = 0.04). TBS protocols may lead to changes in CP when applied over the craniometrically targeted vertex. We therefore suggest not using a conventional approach as a vertex targeting method.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

1435-1463

Volume of the periodical

129

Issue of the periodical within the volume

3

Country of publishing house

AT - AUSTRIA

Number of pages

11

Pages from-to

319-329

UT code for WoS article

000746752700001

EID of the result in the Scopus database

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