Malignant Hyperthermia in PICU-From Diagnosis to Treatment in the Light of Up-to-Date Knowledge

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076466" target="_blank" >RIV/00159816:_____/22:00076466 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/22:00076466 RIV/00216224:14110/22:00127630

Result on the web

<a href="https://www.mdpi.com/2227-9067/9/11/1692" target="_blank" >https://www.mdpi.com/2227-9067/9/11/1692</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/children9111692" target="_blank" >10.3390/children9111692</a>

Result language

angličtina

Original language name

Malignant Hyperthermia in PICU-From Diagnosis to Treatment in the Light of Up-to-Date Knowledge

Original language description

Malignant Hyperthermia (MH) is a rare, hereditary, life-threatening disease triggered by volatile anesthetics and succinylcholine. Rarely, MH can occur after non-pharmacological triggers too. MH was detected more often in children and young adults, which makes this topic very important for every pediatric specialist, both anesthesiologists and intensivists. MH crisis is a life-threatening severe hypermetabolic whole-body reaction. Triggers of MH are used in pediatric intensive care unit (PICU) as well, volatile anesthetics in difficult sedation, status asthmaticus or epilepticus, and succinylcholine still sometimes in airway management. Recrudescence or delayed onset of MH crisis hours after anesthesia was previously described. MH can also be a cause of rhabdomyolysis and hyperpyrexia in the PICU. In addition, patients with neuromuscular diseases are often admitted to PICU and they might be at risk for MH. The most typical symptoms of MH are hypercapnia, tachycardia, hyperthermia, and muscle rigidity. Thinking of the MH as the possible cause of deterioration of a patient&apos;s clinical condition is the key to early diagnosis and treatment. The sooner the correct treatment is commenced, the better patient&apos;s outcome. This narrative review article aims to summarize current knowledge and guidelines about recognition, treatment, and further management of MH in PICU.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30209 - Paediatrics

Project

<a href="/en/project/NU21-06-00363" target="_blank" >NU21-06-00363: Deepening our knowledge about the aetiopathogenesis of Malignant Hyperthermia (MH) and streamlining the diagnostic algorithm MH for the Czech population</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CHILDREN-BASEL

ISSN

2227-9067

e-ISSN

2227-9067

Volume of the periodical

9

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

1692

UT code for WoS article

000882567000001

EID of the result in the Scopus database

2-s2.0-85141799730