Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076624" target="_blank" >RIV/00159816:_____/22:00076624 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/22:00127439
Result on the web
<a href="https://www.nature.com/articles/s41598-022-19121-8" target="_blank" >https://www.nature.com/articles/s41598-022-19121-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-022-19121-8" target="_blank" >10.1038/s41598-022-19121-8</a>

Result language
angličtina
Original language name
Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy
Original language description
The objective was to determine the optimal combination of multimodal imaging methods (IMs) for localizing the epileptogenic zone (EZ) in patients with MR-negative drug-resistant epilepsy. Data from 25 patients with MR-negative focal epilepsy (age 30 +/- 10 years, 16M/9F) who underwent surgical resection of the EZ and from 110 healthy controls (age 31 +/- 9 years; 56M/54F) were used to evaluate IMs based on 3T MRI, FDG-PET, HD-EEG, and SPECT. Patients with successful outcomes and/or positive histological findings were evaluated. From 38 IMs calculated per patient, 13 methods were selected by evaluating the mutual similarity of the methods and the accuracy of the EZ localization. The best results in postsurgical patients for EZ localization were found for ictal/ interictal SPECT (SISCOM), FDG-PET, arterial spin labeling (ASL), functional regional homogeneity (ReHo), gray matter volume (GMV), cortical thickness, HD electrical source imaging (ESI-HD), amplitude of low-frequency fluctuation (ALFF), diffusion tensor imaging, and kurtosis imaging. Combining IMs provides the method with the most accurate EZ identification in MR-negative epilepsy. The PET, SISCOM, and selected MRI-post-processing techniques are useful for EZ localization for surgical tailoring.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30100 - Basic medicine

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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