Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076638" target="_blank" >RIV/00159816:_____/22:00076638 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/22:00129377
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S1388245722008872?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1388245722008872?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clinph.2022.09.002" target="_blank" >10.1016/j.clinph.2022.09.002</a>
Alternative languages
Result language
angličtina
Original language name
Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy
Original language description
Objective: To review the therapeutic effects of deep brain stimulation of the anterior nuclei of the thala-mus (ANT-DBS) and the predictors of its effectiveness, safety, and adverse effects. Methods: A comprehensive search of the medical literature (PubMed) was conducted to identify relevant articles investigating ANT-DBS therapy for epilepsy. Out of 332 references, 77 focused on focal epilepsies were reviewed. Results: The DBS effect is probably due to decreased synchronization of epileptic activity in the cortex. The potential mechanisms from cellular to brain network levels are presented. The ANT might participate actively in the network elaborating focal seizures. The effects of ANT-DBS differed in various studies; ANT-DBS was linked with a 41% seizure frequency reduction at 1 year, 69% at 5 years, and 75% at 7 years. The most frequently reported adverse effects, depression and memory impairment, were considered non -serious in the long-term follow-up view. ANT-DBS also has been used in a few cases to treat status epilep-ticus. Conclusions: We reviewed the clinical literature and identified several factors that may predict seizure outcome following DBS therapy. More large-scale trials are required since there is a need to explore stim-ulation settings, apply patient-tailored therapy, and identify the presurgical predictors of patient response. Significance: A critical review of the published literature on ANT-DBS in focal epilepsy is presented. ANT-DBS mechanisms are not fully understood; possible explanations are provided. Biomarkers of ANT-DBS effectiveness may lead to patient-tailored therapy. (c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/GA21-25953S" target="_blank" >GA21-25953S: Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Neurophysiology
ISSN
1388-2457
e-ISSN
1872-8952
Volume of the periodical
144
Issue of the periodical within the volume
DEC 22
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1-7
UT code for WoS article
000886064800001
EID of the result in the Scopus database
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