Vagus nerve stimulation outcome prediction: from simple parameters to advanced models
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076710" target="_blank" >RIV/00159816:_____/22:00076710 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/22:00129736
Result on the web
<a href="http://www.elis.sk/download_file.php?product_id=7788&session_id=rhdsqlrbjs63gbjmr024us8i14" target="_blank" >http://www.elis.sk/download_file.php?product_id=7788&session_id=rhdsqlrbjs63gbjmr024us8i14</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2022_103" target="_blank" >10.4149/BLL_2022_103</a>
Alternative languages
Result language
angličtina
Original language name
Vagus nerve stimulation outcome prediction: from simple parameters to advanced models
Original language description
Since its approval as an adjunct treatment for refractory partial epilepsy, the positive effects of vagus nerve stimulation (VNS) on seizure frequency and severity have been supported by many studies. Seizure reduction of more than 50 % can be expected in at least 50 % of patients. However, a complete post-VNS seizure freedom is rarely achieved and 25 % of patients do not benefi t from VNS. Our study provides an overview of the potential predictors of VNS response, from the most simple and basic data to sophisticated EEG processing studies and functional imaging studying brain connectivity. The data support better outcomes in younger patients with early VNS implantation, in patients with posttraumatic epilepsy or tuberous sclerosis, and in patients without bilateral interictal epileptiform discharges. The variability of heart activity has also been studied with some promising results. Because the generally accepted hypothesis of the VNS mechanism is the modulation of synaptic activity in multiple cortical and subcortical regions of the brain, the studies of brain response to external stimulation and/or of brain connectivity were used for models predicting the effect of VNS in individual patients. Although the predictive value of these models is high, the required special equipment and sophisticated mathematical tools limit their routine use (C) 2022. Bratislava Medical Journal. All Rights Reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30200 - Clinical medicine
Result continuities
Project
<a href="/en/project/NV19-04-00343" target="_blank" >NV19-04-00343: Prediction of Stimulation Efficacy in Epilepsy (PRESEnCE)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislavské Lekárske Listy
ISSN
0006-9248
e-ISSN
—
Volume of the periodical
123
Issue of the periodical within the volume
9
Country of publishing house
SK - SLOVAKIA
Number of pages
7
Pages from-to
641-647
UT code for WoS article
000903730000006
EID of the result in the Scopus database
2-s2.0-85135856094