Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077349" target="_blank" >RIV/00159816:_____/22:00077349 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/22:00126526 RIV/65269705:_____/22:00077349

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fcimb.2022.943480/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcimb.2022.943480/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcimb.2022.943480" target="_blank" >10.3389/fcimb.2022.943480</a>

Result language

angličtina

Original language name

Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study

Original language description

Severe Early Childhood Caries (sECC) is a multifactorial disease associated with the occurrence of specific oral microorganisms and other environmental, behavioral, and genetic factors. This study aimed to construct a multivariable model including the occurrence of Candida spp. and selected behavioral factors (length of breastfeeding, serving sweet beverages and beginning of brushing child&apos;s teeth) to determine their relationships to the occurrence of sECC.In this case-control study 164 children with sECC and 147 children without dental caries were included. MALDI-TOF MS and multiplex qPCR were used to identify Candida spp. and selected bacteria in dental plaque samples, respectively. A questionnaire on oral hygiene, diet, and children&apos;s health was filled in by the parents.The constructed multivariable logistic regression model showed an independent influence of the microbial and behavioral factors in sECC etiopathogenesis. The occurrence of C. albicans and C. dubliniensis was associated with higher odds of sECC development (odds ratio, OR: 9.62 and 16.93, respectively), together with breastfeeding of 6 months or less (OR: 2.71), exposure to sweet beverages (OR: 3.77), and starting to brush child&apos;s teeth after the 12(th) month of age (OR: 4.10), all statistically significant (p &lt; 0.01).Considering the high occurrence of C. albicans and C. dubliniensis in dental plaque in children with sECC, we propose them as &quot;keystone pathogens&quot; and risk factors for sECC. The models showed that presence of specific species of Candida in dental plaque may be a better descriptor of sECC than the mentioned behavioral factors.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Cellular and Infection Microbiology

ISSN

2235-2988

e-ISSN

2235-2988

Volume of the periodical

12

Issue of the periodical within the volume

Jul

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

943480

UT code for WoS article

000838089400001

EID of the result in the Scopus database

2-s2.0-85136341692