Train the Trainer: Hematopoietic Stem Cell Control of Trained Immunity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077582" target="_blank" >RIV/00159816:_____/22:00077582 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/22:00013390

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2022.827250/full#h7" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2022.827250/full#h7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2022.827250" target="_blank" >10.3389/fimmu.2022.827250</a>

Result language

angličtina

Original language name

Train the Trainer: Hematopoietic Stem Cell Control of Trained Immunity

Original language description

Recent evidence shows that innate immune cells, in addition to B and T cells, can retain immunological memory of their encounters and afford long-term resistance against infections in a process known as &apos;trained immunity&apos;. However, the duration of the unspecific protection observed in vivo is poorly compatible with the average lifespan of innate immune cells, suggesting the involvement of long-lived cells. Accordingly, recent studies demonstrate that hematopoietic stem and progenitor cells (HSPCs) lay at the foundation of trained immunity, retaining immunological memory of infections and giving rise to a &quot;trained&quot; myeloid progeny for a long time. In this review, we discuss the research demonstrating the involvement of HSPCs in the onset of long-lasting trained immunity. We highlight the roles of specific cytokines and Toll-like receptor ligands in influencing HSPC memory phenotypes and the molecular mechanisms underlying trained immunity HSPCs. Finally, we discuss the potential benefits and drawbacks of the long-lasting trained immune responses, and describe the challenges that the field is facing.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

January

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

nestrankovano

UT code for WoS article

000753615700001

EID of the result in the Scopus database

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