Pharmacokinetics of colistin during extracorporeal membrane oxygenation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077615" target="_blank" >RIV/00159816:_____/22:00077615 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/22:00127663
Result on the web
<a href="https://academic.oup.com/jac/article-abstract/77/8/2298/6591052?redirectedFrom=fulltext&login=true" target="_blank" >https://academic.oup.com/jac/article-abstract/77/8/2298/6591052?redirectedFrom=fulltext&login=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jac/dkac163" target="_blank" >10.1093/jac/dkac163</a>

Result language
angličtina
Original language name
Pharmacokinetics of colistin during extracorporeal membrane oxygenation
Original language description
During the recent COVID-19 pandemic, several patients required extracorporeal membrane oxygenation (ECMO) due to COVID-19 infection complicated by ventilator-associated pneumonia caused by MDR Pseudomonas aeruginosa that was only susceptible to colistin.Extracorporeal circuits, in general, represent another compartment that increases the volume of distribution for hydrophilic compounds and may affect drug clearance.1 Besides that, ECMO can, more importantly, influence pharmacokinetics by drug adsorption on the circuit surface. This phenomenon is influenced by physicochemical properties of the medication - mainly lipophilicity and protein binding - but it is also dependent on particular materials of circuit components and circuit coating. Since both colistin and its prodrug colistin methanesulfonate (CMS) are hydrophilic substances (logP MINUS SIGN 2.4 for colistin) with medium protein binding (approx. 50% for colistin), adsorption on the ECMO circuit seems unlikely. We have not found any data on potential adsorption on an ECMO circuit; however, adsorption on the polysulphone membrane dialyser was described.2 Therefore, we were concerned about the reduced plasma levels and disturbed effectiveness of colistin therapy in our patients.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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