Different Profiles of Spatial Navigation Deficits In Alzheimer's Disease Biomarker-Positive Versus Biomarker-Negative Older Adults With Amnestic Mild Cognitive Impairment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077663" target="_blank" >RIV/00159816:_____/22:00077663 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/22:10444667 RIV/00216208:11130/22:10444667

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fnagi.2022.886778/full#h10" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnagi.2022.886778/full#h10</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnagi.2022.886778" target="_blank" >10.3389/fnagi.2022.886778</a>

Result language

angličtina

Original language name

Different Profiles of Spatial Navigation Deficits In Alzheimer's Disease Biomarker-Positive Versus Biomarker-Negative Older Adults With Amnestic Mild Cognitive Impairment

Original language description

BackgroundSpatial navigation impairment is a promising cognitive marker of Alzheimer&apos;s disease (AD) that can reflect the underlying pathology. ObjectivesWe assessed spatial navigation performance in AD biomarker positive older adults with amnestic mild cognitive impairment (AD aMCI) vs. those AD biomarker negative (non-AD aMCI), and examined associations between navigation performance, MRI measures of brain atrophy, and cerebrospinal fluid (CSF) biomarkers. MethodsA total of 122 participants with AD aMCI (n = 33), non-AD aMCI (n = 31), mild AD dementia (n = 28), and 30 cognitively normal older adults (CN) underwent cognitive assessment, brain MRI (n = 100 had high-quality images for volumetric analysis) and three virtual navigation tasks focused on route learning (body-centered navigation), wayfinding (world-centered navigation) and perspective taking/wayfinding. Cognitively impaired participants underwent CSF biomarker assessment [amyloid-beta(1-42), total tau, and phosphorylated tau(181) (p-tau(181))] and amyloid PET imaging (n = 47 and n = 45, respectively), with a subset having both (n = 19). ResultsIn route learning, AD aMCI performed worse than non-AD aMCI (p &lt; 0.001), who performed similarly to CN. In wayfinding, aMCI participants performed worse than CN (both p &lt;= 0.009) and AD aMCI performed worse than non-AD aMCI in the second task session (p = 0.032). In perspective taking/wayfinding, aMCI participants performed worse than CN (both p &lt;= 0.001). AD aMCI and non-AD aMCI did not differ in conventional cognitive tests. Route learning was associated with parietal thickness and amyloid-beta(1-42), wayfinding was associated with posterior medial temporal lobe (MTL) volume and p-tau(181) and perspective taking/wayfinding was correlated with MRI measures of several brain regions and all CSF biomarkers. ConclusionAD biomarker positive and negative older adults with aMCI had different profiles of spatial navigation deficits that were associated with posterior MTL and parietal atrophy and reflected AD pathology.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30227 - Geriatrics and gerontology

Project

<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Aging Neuroscience

ISSN

1663-4365

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

June

Country of publishing house

CH - SWITZERLAND

Number of pages

24

Pages from-to

nestrankovano

UT code for WoS article

000811841400001

EID of the result in the Scopus database

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