Polymorphisms in some proinflammatory genes (TNF alpha and beta, IL-1 beta, IL-6, ADAM17) in severe chronic venous disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00077840" target="_blank" >RIV/00159816:_____/23:00077840 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00130206

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.18770" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.18770</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jdv.18770" target="_blank" >10.1111/jdv.18770</a>

Result language

angličtina

Original language name

Polymorphisms in some proinflammatory genes (TNF alpha and beta, IL-1 beta, IL-6, ADAM17) in severe chronic venous disease

Original language description

BackgroundChronic venous disease (CVD) is a common disorder of lower extremities. ObjectivesThe study was scheduled to investigate the relationship between polymorphisms in major proinflammatory genes TNF alpha (-238 A/G; -308 A/G), TNF beta (NcoI), IL-1 beta (+3953 T/C); IL-6 (-174 G/C; -596 G/C) and ADAM17 (3 &apos; TACE) and CVD risk. Genotype-phenotype study was calculated to test possible association between examined genotypes and phenotypes of CVD. MethodsFinally, 150 CVD patients and 227 control subjects were enrolled to the study.Genotypes in proinflammatory gene polymorphisms were identified from isolated DNA by PCR method and restriction analysis. ResultsSignificant differences in genotype distribution/allelic frequencies in TNF beta gene, IL-1 beta gene and in ADAM17 gene polymorphisms were found between CVD women and control ones. In the genotype-phenotype study, identified genotypes were associated with arterial hypertension (ADAM17, IL-6-men), ischaemic heart disease (TNF alpha and beta genes), diabetes mellitus (ADAM17-women, TNF beta-men), age of CVD onset (TNF alpha and IL-6), ulceration (ADAM17), duration of ulceration (ADAM17), ulceration recurrence (ADAM17-women), home care necessity (TNF alpha), varices surgery (TNF alpha), erysipelas development (ADAM17-men) and tumour development (TNF alpha). ConclusionStudying of these polymorphisms associations can help us better identify patients at higher risk of developing severe CVD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30216 - Dermatology and venereal diseases

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of European Academy of Dermatology Venereology

ISSN

0926-9959

e-ISSN

1468-3083

Volume of the periodical

37

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

590-597

UT code for WoS article

000897650900001

EID of the result in the Scopus database

2-s2.0-85143540501