Birth outcomes, puberty onset, and obesity as long-term predictors of biological aging in young adulthood

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00077885" target="_blank" >RIV/00159816:_____/23:00077885 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/23:00130447 RIV/65269705:_____/23:00077885

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fnut.2022.1100237/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnut.2022.1100237/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnut.2022.1100237" target="_blank" >10.3389/fnut.2022.1100237</a>

Result language

angličtina

Original language name

Birth outcomes, puberty onset, and obesity as long-term predictors of biological aging in young adulthood

Original language description

BackgroundBiological aging and particularly the deviations between biological and chronological age are better predictors of health than chronological age alone. However, the predictors of accelerated biological aging are not very well understood. The aim was to determine the role of birth outcomes, time of puberty onset, body mass index (BMI), and body fat in accelerated biological aging in the third decade of life. MethodsWe have conducted a second follow-up of the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) prenatal birth cohort in young adulthood (52% male; age 28-30; n = 262) to determine the role of birth outcomes, pubertal timing, BMI, and body fat on biological aging. Birth outcomes included birth weight, length, and gestational age at birth. Pubertal timing was determined by the presence of secondary sexual characteristics at the age of 11 and the age of first menarche in women. Biological age was estimated using the Klemera-Doubal Method (KDM), which applies 9-biomarker algorithm including forced expiratory volume in one second (FEV1), systolic blood pressure, glycated hemoglobin, total cholesterol, C-reactive protein, creatinine, urea nitrogen, albumin, and alkaline phosphatase. Accelerated/decelerated aging was determined as the difference between biological and chronological age (BioAGE). ResultsThe deviations between biological and chronological age in young adulthood ranged from -2.84 to 4.39 years. Accelerated biological aging was predicted by higher BMI [in both early (R-adj(2) = 0.05) and late 20s (R-adj(2) = 0.22)], subcutaneous (R-adj(2) = 0.21) and visceral fat (R-adj(2) = 0.25), puberty onset (eta(2)(p) = 0.07), birth length (R-adj(2) = 0.03), and the increase of BMI over the 5-year period between the two follow-ups in young adulthood (R-adj(2) = 0.09). Single hierarchical model revealed that shorter birth length, early puberty onset, and greater levels of visceral fat were the main predictors, together explaining 21% of variance in accelerated biological aging. ConclusionOur findings provide comprehensive support of the Life History Theory, suggesting that early life adversity might trigger accelerated aging, which leads to earlier onset of puberty but decreasing fitness in adulthood, reflected by more visceral fat and higher BMI. Our findings also suggest that reduction of BMI in young adulthood slows down biological aging.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30308 - Nutrition, Dietetics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

—

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Nutrition

ISSN

2296-861X

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

JAN 10

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

1100237

UT code for WoS article

000919818000001

EID of the result in the Scopus database

2-s2.0-85147036421