Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10-17-year follow-up study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00078044" target="_blank" >RIV/00159816:_____/23:00078044 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/23:00078044 RIV/00216224:14110/23:00134637

Result on the web

<a href="https://link.springer.com/article/10.1007/s00381-023-05992-3" target="_blank" >https://link.springer.com/article/10.1007/s00381-023-05992-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00381-023-05992-3" target="_blank" >10.1007/s00381-023-05992-3</a>

Result language

angličtina

Original language name

Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10-17-year follow-up study

Original language description

PurposeA retrospective study, based on a prospectively built database, presents the results of long-term follow-up care of pediatric vagus nerve stimulation (VNS) patients in terms of seizure outcome, surgical aspects, the potential impact of maturation, and medication changes.MethodsFrom a prospectively built database, 16 VNS patients (median age 12.0 years, range 6.0 to 16.0 years; median seizure duration 6.5 years, range 2.0 to 15.5 years) followed for at least 10 years were graded as non-responder - NR (seizure frequency reduction &lt; 50%), responder - R (reduction &gt;= 50% and &lt; 80%), and 80% responder - 80R (reduction &gt;= 80%). Data about surgical aspects (battery replacement, system complications), seizure dynamics, and medication changes were taken from the database.ResultsThe early percentages of good results (80R + R) were 43.8% (year 1), 50.0% (year 2), and 43.8% (year 3). These percentages remained stable between years 10 and 12 (50% year 10; 46.7% year 11; 50% year 12) and increased in years 16 (60%) and 17 (75%). Depleted batteries were replaced in ten patients, six of whom were either R or 80R. In the four NR, the indication for replacement was improved quality of life. Three patients had VNS explanted or switched off-one had repeated asystolia and two were NR. The effect of hormonal changes in menarche on seizure was not proven. During the study, antiseizure medication was changed in all patients.ConclusionsThe study proved the efficacy and safety of VNS in pediatric patients over an exceptionally long follow-up period. The demand for battery replacements indicates a positive treatment effect.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

<a href="/en/project/NV19-04-00343" target="_blank" >NV19-04-00343: Prediction of Stimulation Efficacy in Epilepsy (PRESEnCE)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Childs Nervous System

ISSN

0256-7040

e-ISSN

1433-0350

Volume of the periodical

39

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

3215-3224

UT code for WoS article

000992036000001

EID of the result in the Scopus database

2-s2.0-85160276810