Bariatric surgery and its impact on depressive symptoms, cognition, brain and inflammation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00078849" target="_blank" >RIV/00159816:_____/23:00078849 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/23:00133482
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fendo.2023.1171244/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fendo.2023.1171244/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fendo.2023.1171244" target="_blank" >10.3389/fendo.2023.1171244</a>
Alternative languages
Result language
angličtina
Original language name
Bariatric surgery and its impact on depressive symptoms, cognition, brain and inflammation
Original language description
BackgroundObesity has been associated with depressive symptoms and impaired cognition, but the mechanisms underlying these relationships are not well understood. It is also not clear whether reducing adiposity reverses these behavioral outcomes. The current study tested the impact of bariatric surgery on depressive symptoms, cognition, and the brain; using a mediation model, we also examined whether the relationship between changes in adiposity after the surgery and those in regional thickness of the cerebral cortex are mediated by changes in low-grade inflammation (as indexed by C-reactive protein; CRP). MethodsA total of 18 bariatric patients completed 3 visits, including one baseline before the surgery and two post-surgery measurements acquired at 6- and 12-months post-surgery. Each visit consisted of a collection of fasting blood sample, magnetic resonance imaging of the brain and abdomen, and assessment of depressive symptoms and cognition. ResultsAfter surgery, we observed reductions of both visceral fat (p< 0.001) and subcutaneous fat (p< 0.001), less depressive symptoms (p< 0.001), improved verbal reasoning (p< 0.001), and reduced CRP (p< 0.001). Mediation analyses revealed that the relationships between the surgery-related changes in visceral fat and cortical thickness in depression-related regions are mediated by changes in CRP (ab=-.027, SE=.012, 95% CI [-.054, -,006]). ConclusionThese findings suggest that some of the beneficial effects of bariatric surgery on brain function and structure are due to a reduction of adiposity-related low-grade systemic inflammation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Endocrinology
ISSN
1664-2392
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
JUL 6
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
1171244
UT code for WoS article
001029987300001
EID of the result in the Scopus database
2-s2.0-85165243026