Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00079521" target="_blank" >RIV/00159816:_____/24:00079521 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00135520 RIV/61988987:17110/24:A2503AL3 RIV/00216208:11130/24:10477961 RIV/00216305:26220/24:PU151066 and 3 more
Result on the web
<a href="https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1360385/full" target="_blank" >https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1360385/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fneur.2024.1360385" target="_blank" >10.3389/fneur.2024.1360385</a>

Result language
angličtina
Original language name
Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment
Original language description
In this prospective study involving 37 Duchenne muscular dystrophy (DMD) patients aged 8-18 years and older, we examined the impact of neurological and cardiac factors on quality of life (QoL). Our findings revealed a negative correlation between upper limb movement and overall mobility, self-service, and usual activities. Ambulatory and non-ambulatory DMD patients showed significant differences in mobility-related parameters. Cardiac evaluations demonstrated associations between mitral annular plane systolic excursion (MAPSE) and mobility-related aspects. The PEDSQL 3.0 neuromuscular model questionnaire further highlighted age-related and movement-related correlations with QoL. The loss of ambulatory status and reduced upper limb movement were negatively associated with QoL, while upper limb movement positively correlated with septal MAPSE. However, no significant associations were found between MAPSE and anxiety/depression. These findings underscore the multifaceted impact of DMD on QoL and emphasize the importance of considering both neurological and cardiac factors in comprehensive patient care.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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