Diabetes mellitus in stable chronic heart failure and the combination with humoral activation, their association, and prediction of 2-year adverse outcomes. Data from the FAR NHL registry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00080372" target="_blank" >RIV/00159816:_____/24:00080372 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00137178 RIV/00216208:11130/24:10484828 RIV/65269705:_____/24:00080372 RIV/00064203:_____/24:10484828 RIV/00023884:_____/24:00010004

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.13605" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.13605</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1753-0407.13605" target="_blank" >10.1111/1753-0407.13605</a>

Result language

angličtina

Original language name

Diabetes mellitus in stable chronic heart failure and the combination with humoral activation, their association, and prediction of 2-year adverse outcomes. Data from the FAR NHL registry

Original language description

Background/Aim: The study aims to describe the role of diabetes in patients with heart failure. Methods: In all, 1052 chronic heart failure patients were included in the FARmacology and NeuroHumoral Activation (FAR NHL) multicenter prospective registry. They had ejection fraction below 50% and were on stable medication for at least 1 month. Results: More than one-third (38.9%) of the patients had diabetes mellitus (DM). Diabetic patients (N N = 409) were older (median 67 vs. 64, p &lt; 0.001), had higher body mass index (BMI) (30 vs. 28 kg/m(2), p &lt; 0.001), much more frequently had ischemic heart disease (71 vs. 47%, p &lt; 0.001), hypertension (80 vs. 67%, p &lt; 0.001), dyslipidemia (89 vs. 69%, p &lt; 0.001), worse renal function (estimated glomerular filtration rate [eGFR] median 63 vs. 73 mL/min/ 1.73 m(2), p &lt; 0.001), and higher N-terminal pro-brain natriuretic peptide (NTproBNP) (median 681 vs. 463 pg/mL, p = 0.003). All-cause death, left ventricle assist device implantation, and orthotopic heart transplantation were set as the combined primary end point, which was present in 15.5% (163 patients) within the 2-year follow-up. In the 2-year follow-up, 81.0% of patients with diabetes survived without a primary end point, while 85.4% of the patients without diabetes survived, the difference being on the verge of statistical significance (p = 0.089). DM is a statistically significant predictor of NT-proBNP value in univariate analysis, but it is not an independent predictor in a multivariate analysis. When the NT-proBNP level was high, the presence of DM did not influence the prognosis. Conclusion: The combination of diabetes and NT-proBNP levels may better stratify the prognosis of patients with chronic heart failure.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Diabetes

ISSN

1753-0393

e-ISSN

1753-0407

Volume of the periodical

16

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

"e13605"

UT code for WoS article

001310603500001

EID of the result in the Scopus database

2-s2.0-85203517235